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Other potential causes In rare cases, acanthosis nigricans can occur due to: stomach cancer, or gastric adenocarcinoma adrenal gland disorders, such as Addisons disease disorders of the pituitary gland low levels of thyroid hormones high doses of niacin some types of stomach cancer genetics some autoimmune disorders like Sjgrens disease or Hashimotos thyroiditis Who is at risk for acanthosis nigricans

Therefore, outside of unique case-by case patient specific scenarios, Health Canada considers this activity to be manufacturing

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The lower lip is particularly affected because of its angle of exposure to sunlight